Genetic characterization of newly developed mutant hairless mice “HR^CDRI”

546-551 Newly developed mutant hairless mice and two outbred mouse strains (Park and Swiss) were examined at 16 loci encoding proteins and enzymes in cellulose acetate electrophoresis. Genetic variation as per cent polymorphism (P%=43.7), observed heterozygosity (Hob=0.02±0.071), expected heterozygosity (HE=0.175±0.229) and even genetic distance values (D=0.1348 in hairless Vs Swiss; D=0.1688 in hairless Vs Park and D=0.0686 in Swiss Vs Park) were found completely different in hairless strain. Seven protein biochemical markers loci (Akp-I, Car-I, Ce-2, Es-3, Idh-I, Mod-I and Pep-3) were polymorphic in hairless mice. Rest of the loci including locus Es-10 on chromosome no. 14, which is responsible for hr/hr locus (hairless, recessive) mutation for HRS/J strain were found monomorphic and also similar to that of HRS/J strain. Hence, present outbred strain may be designated as “HRcdri” which can be developed as a first inbred line of hairless mice like HRS/J strain in India. A detailed study of mtDNA/microsatellite marker sequencing could lend more support to this study.